Ineffabilis Deus defines the Immaculate Conception and relied heavily on Genesis 3. The Pope gives his definition on Genesis 3:15 in the following words:

These ecclesiastical writers in quoting the words by which at the beginning of the world God announced his merciful remedies prepared for the regeneration of mankind — words by which HE crushed the audacity of the deceitful serpent and wondrously raised up the hope of our race, saying, “I will put enmities between you and the woman, between your seed and her seed”^[13] — taught that by this divine prophecy the merciful Redeemer of mankind, Jesus Christ, the only begotten Son of God, was clearly foretold: That his most Blessed Mother, the Virgin Mary, was prophetically indicated; and, at the same time, the very enmity of both against the evil one was significantly expressed. Hence, just as Christ, the Mediator between God and man, assumed human nature, blotted the handwriting of the decree that stood against us, and fastened it triumphantly to the cross, so the most holy Virgin, united with him by a most intimate and indissoluble bond, was, with him and through him, eternally at enmity with the evil serpent, and most completely triumphed over him, and thus crushed his head with her immaculate foot.

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